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Prescription GLP-1 treatments have been tested in large, long-running clinical trials involving thousands of participants: Semaglutide 2.4 mg (Wegovy) participants lost an average of around 1521% of their body weight over 6872 weeks in the STEP trials Tirzepatide (Mounjaro) the SURMOUNT trials showed average weight loss of 2025% of starting body weight at the highest dose over 72 weeks These results come from rigorously controlled studies with safety monitoring, dose titration, and long-term follow-up

Tumasian, R

Smokers in the same trial smoked less as well

For someone who wants a hand to hold, it is a shortcoming

SSTRs, particularly SSTR2 and SSTR5, are highly expressed on somatotrophs in GH-secreting pituitary tumors, in which SSAs inhibits GH secretion by impeding adenylyl cyclase and decreasing cAMP levels 15,16

It is typically worst in the first two months and improves significantly as the body adjusts